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骨重塑:确保生存和骨力学能力的操作过程
Bone Research
(
IF
14.3
)
Pub Date : 2022-07-18
, DOI:
10.1038/s41413-022-00219-8
Simona Bolamperti
1
,
Isabella Villa
1
,
Alessandro Rubinacci
1
Affiliation
- Osteoporosis and Bone and Mineral Metabolism Unit, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132, Milano, Italy.
骨骼重塑通过在同一表面上发生的一系列细胞事件用新骨骼替换旧的和受损的骨骼,而骨骼形状没有任何变化。最初认为,负责骨重塑的基本多细胞单元 (BMU) 由破骨细胞和成骨细胞组成,这些细胞通过组织成不同阶段的分层事件序列发挥作用。然而,最近的发现表明,所有骨细胞通过同时和在不同分化阶段与其祖细胞、其他细胞和骨基质成分相互作用来参与 BMU 的形成。因此,骨重塑目前被认为是优化以赋予生存优势的连续细胞操作过程的生理结果。骨骼重塑定义了 BMU 成功更新骨骼结构单元所需执行的主要活动。因此,本综述总结了目前对骨重塑的理解和未来的研究方向,旨在提供临床相关的生物学背景,从而确定骨质疏松症治疗策略的靶点。
"点击查看英文标题和摘要"
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape. It was initially thought that the basic multicellular unit (BMU) responsible for bone remodeling consists of osteoclasts and osteoblasts functioning through a hierarchical sequence of events organized into distinct stages. However, recent discoveries have indicated that all bone cells participate in BMU formation by interacting both simultaneously and at different differentiation stages with their progenitors, other cells, and bone matrix constituents. Therefore, bone remodeling is currently considered a physiological outcome of continuous cellular operational processes optimized to confer a survival advantage. Bone remodeling defines the primary activities that BMUs need to perform to renew successfully bone structural units. Hence, this review summarizes the current understanding of bone remodeling and future research directions with the aim of providing a clinically relevant biological background with which to identify targets for therapeutic strategies in osteoporosis.
更新日期:2022-07-18