Technology that changes everything

Engineered with your practice and your patients in mind, the Auryon System is designed with industry-leading technology and features that allow you to treat any lesion you encounter, all with a single device built to streamline how you handle PAD.^1-3

The device The science

The Auryon System for peripheral atherectomy in PAD treatment

Welcome to what’s next

With the Auryon System, you get to harness the next generation of peripheral atherectomy technology.

ADAPTABLE

Treats all levels of calcification^1-3

Indicated for in-stent restenosis*
Treats infrainguinal lesions both above and below the knee (including below the ankle)
Built-in off-centering mechanism for eccentric lesions in largest catheter

*Only the 2.0- and 2.35-mm catheters are indicated for ISR.

PRECISE

Protective of the vessel wall^3-5

Performs targeted biological reactions to address risk of perforations
Nonreactive to contrast media for simultaneous ablation and observation of fluoroscopy image
Includes built-in aspiration to address risk of embolization^†

^†Built-in aspiration available only with the 2.0- and 2.35-mm catheters.

EFFICIENT

Designed for your lab^1-3,6

Designed to be portable, uses a 110V outlet, has a touch screen, and emits low acoustic noise
Has the potential to debulk in fewer passages
Small footprint, easy installation and storage

The device

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The front of the Auryon System for peripheral atherectomy in PAD treatment

The back of the Auryon System for peripheral atherectomy in PAD treatment

The Auryon System catheters for peripheral atherectomy in PAD treatment

Select each icon

to discover features.

Intuitive touch-screen controls

LED activity status indicator

Solid-state laser contains no gas and requires no calibration

Foot pedal for hands-free activation

Aspiration available with 2 catheters

The front of the Auryon System for peripheral atherectomy in PAD treatment

Ergonomic maneuverability

Small footprint in your office space

Standard 110V wall plug

Foot pedal and power cord storage

The back of the Auryon System for peripheral atherectomy in PAD treatment

Below the knee/ankle
Reference vessel diameter: ≥1.4 mm²

Below the knee
Reference vessel diameter: ≥2.25 mm²

Reference vessel diameter: ≥3.0 mm²
Built-in aspiration capability
Cleared for ISR

Reference vessel diameter: ≥3.6 mm²
Built-in aspiration capability
Off-centering mechanism
Cleared for ISR

The Auryon System catheters for peripheral atherectomy in PAD treatment

Advanced efficiency³

Weight 198 lb
Length 29 in
Height 37 in
Width 13.3 in
Wavelength 355 nm class IV laser system
Power type 110V wall outlet
Small footprint, lightweight portability, and convenient storage for your office.

Weight 650 lb
Length 49 in
Height 41.9 in
Width 24 in
Wavelength 308 nm class IV laser system
Power type 208-230 VAC single phase power US wall outlet receptacle NEMA L6-30R, Hubble Part # HBL2620, 250BAC, 30A wall mount twist lock⁷

Treat any infrainguinal artery^1,3

Purpose-built catheters are designed to treat both above and below the knee, including the ankle.

Transparent left leg illustration showing infrainguinal vasculature

Popliteal + superficial
femoral artery

2.35-mm catheter

Reference vessel diameter: ≥3.6 mm²
Built-in aspiration capability
Off-centering mechanism
Cleared for ISR
French size 7 Fr

Femoropopliteal +
tibioperoneal trunk

2.0-mm catheter

Reference vessel diameter: ≥3.0 mm²
Built-in aspiration capability
Cleared for ISR
French size 6 Fr

Tibial + femoropopliteal

1.5-mm catheter

Below the knee
Reference vessel diameter: ≥2.25 mm²
French size 5 Fr
Now available in 225cm XL length

Below the ankle + tibials

0.9-mm catheter

Reference vessel diameter: ≥1.4 mm²
French size 4 Fr
Now available in 225cm XL length

All catheters work over a standard 0.014-inch guide-wire.

The science

Powerful. And precise.

The Auryon System is designed to deliver an optimized wavelength, pulse width, and amplitude to remove calcified lesions while preserving vessel wall endothelium.^3,4,8

Wavelength, pulse width, and amplitude image

Wavelength (nm)
The distance between 2 successive waves determines absorption rate and penetration depth

Pulse width (ns)
The duration of each pulse determines levels of diffusion

Amplitude (mJ/mm²)
The height of the wave determines power

Why wavelength matters^9-12

Each type of tissue interacts differently with a given wavelength
To initiate a photochemical effect, the photon energy of the beam must be higher than the dissociation energy of the target molecular bond
Longer wavelengths are absorbed at shallower depths than shorter wavelengths, resulting in lower photon energies

The Auryon System produces a photon energy of 3.5 eV, which is low enough to be nonreactive to vessel endothelium, but high enough to vaporize calcium.^4,8

Why pulse width and amplitude matter^9,11,13,14

To localize the effects to the target tissue without thermal damage, the energy delivered needs to be faster than the time it takes for the heat to diffuse
As the type of plaque progresses from visible intimal thickening to hard, the amplitude (power) needed to ablate increases
Greater amplitude is achieved with shorter pulses, which can deposit energy before thermal diffusion occurs

The Auryon System has a pulse width of 10 to 25 ns, ensuring enough power to target the lesion and spare the vessel.³

How the Auryon System combines power and precision

The precision of 355-nm wavelength^4,5

3x higher affinity for lesion tissue vs vessel endothelium, giving you the ability to ablate the lesion while preserving vessel endothelium
Nonreactive to contrast media, allowing you to simultaneously debulk lesions and monitor fluoroscopy images

Power to debulk any type of lesion (from thrombotic to severely calcified)^3,8

10- to 25-ns pulse width with 40-Hz amplitude allows for high power output, resulting in calcium debulking
Plasma formation results in vaporization of lesion tissue without thermal ablation

Efficient ablation

A shorter pulse is efficient at material removal by delivering more of the total energy above the biological threshold.¹⁴

Efficient ablation graph

See how the Auryon System performed in a multinational trial with 97 patients.^1-3

Trial data

References: 1. Rundback J, Chandra P, Brodmann M, Weinstock B, Sedillo G, Cawich I, et al. Novel laser-based catheter for peripheral atherectomy: 6-month results from the Eximo Medical B-Laser™ IDE study. Catheter Cardiovasc Interv. 2019;1-8. 2. Shammas NW, Chandra P, Brodmann M, Weinstock B, Sedillo G, Cawich I, et al. Acute and 30-day safety and effectiveness evaluation of Eximo Medical’s B-Laser™, a novel atherectomy device, in subjects affected with infrainguinal peripheral arterial disease: Results of the EX-PAD-03 trial. Cardiovas Revasc Med. 2020;21(1):86-92. 3. Auryon. Instructions for use. AngioDynamics; 2019. 4. Herzog A, Bogdan S, Glikson M, Ishaaya AA, Love C. Selective tissue ablation using laser radiation at 355 nm in lead extraction by a hybrid catheter; a preliminary report. Lasers Surg Med. 2016;48(3):281-287. 5. Herzog A, Steinberg I, Gaisenberg E, Nomberg R, Ishaaya AA. A route to laser angioplasty in the presence of fluoroscopy contrast media, using a nanosecond-pulsed 355-nm laser. IEEE J Sel Top Quantum Electron. 2016;22(3):342-347. 6. Kuczmik W, Kruszyna L, Stanisic MG, Dzieciuchowicz L, Ziaja K, Zelawski W, et al. Laser atherectomy using the novel B-Laser™ catheter, for the treatment of femoropopliteal lesions: twelve-month results from the EX-PAD-01 study. Not yet published. 7. Spectranetics Corporation. CVX-300 Excimer Laser System: Operator’s Manual. Version 28. 2019:1-56. 8. Vogel A, Venugopalan V. Mechanisms of pulsed laser ablation of biological tissues. Chem Rev. 2003;103(2):577-644. 9. Akkus NI, Abdulbaki A, Jimenez E, Tandon N. Atherectomy devices: technology update. Med Devices (Auckl). 2015;8:1-10. 10. Rawlins J, Din JN, Talwar S, O’Kane P. Coronary intervention with the Excimer laser: review of the technology and outcome data. Interv Cardiol. 2016;11(1):27-32. 11. Jacques SL. Role of tissue optics and pulse duration on tissue effects during high-power laser irradiation. Appl Opt. 1993;32(13):2447-2454. 12. Beek JF, van der Meulen FW, Gijsbers GHM, Welch AJ, Hogervorst W, van Gemert MJC. Laser physics and laser-tissue interaction. Laser Surg Child. 1998;10-49. 13. Taylor RS, Higginson LAJ, Leopold KE. Dependence of the XeCl laser cut rate of plaque on the degree of calcification, laser fluence, and optical pulse duration. Lasers Surg Med. 1990;10(5):414-419. 14. Photonics Media. Shorter pulse widths improve micromachining. https://www.photonics.com/Articles/Shorter_Pulse_Widths_Improve_Micromachining/a54123. Published June 2013. Accessed March 20, 2020.

Technology that changes everything

Welcome to what’s next

The device

Advanced efficiency3

Treat any infrainguinal artery1,3

The science

Powerful. And precise.

How the Auryon System combines power and precision

See how the Auryon System performed in a multinational trial with 97 patients.1-3

Advanced efficiency³

Treat any infrainguinal artery^1,3

See how the Auryon System performed in a multinational trial with 97 patients.^1-3